Blomfield IMRB, Masdeu MDM, Mulugeta E, Vaga S, van den Berg DL, Huillard E, Guillemot F, Urbn N (2019) Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells
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Melatonin levels urinary 6-sulfatoxymelatonin (overnight collection) is the standard research measure Cortisol rhythm morning and evening salivary cortisol to assess circadian regulation Inflammatory markers hsCRP, IL-6 as general aging biomarkers Fasting glucose and insulin epithalamin showed effects on glucose metabolism in aged primates (Khavinson et al., 2005) Subjective Tracking Energy journal daily 1-10 rating at consistent times Skin quality photos same lighting, same angle, monthly Recovery from exercise or minor illness note any changes in bounce-back time Mood and cognitive clarity brief daily notes Best Practices Documented tracking approaches establish all baselines before the first Epitalon cycle, with biomarkers tested at least 2 weeks before starting
For instance, Ekdahl and colleagues found that administration of minocycline, an anti-inflammatory drug, restored neurogenesis in the hippocampus and reduced activated microglia [99]
